Red Blood Cell Aggregation

Red Blood Cell Aggregation

Red blood cells in humans—and most other mammals—have a tendency to form aggregates with a characteristic face-to-face morphology, similar to a stack of coins. Known as rouleaux, these aggregates are a normally occurring phenomenon and have a major impact on blood rheology. What is the underlying mechanism that produces this pattern? Does this really happen in blood circulation? And do these rouleaux formations have a useful function? The first book to offer a comprehensive review of the subject, Red Blood Cell Aggregation tackles these and other questions related to red blood cell (RBC) aggregates. The book covers basic, clinical, and physiological aspects of this important biophysical phenomenon and integrates these areas with concepts in bioengineering. It brings together state-of-the-art research on the determinants, mechanisms, and measurement and effects of RBC aggregation as well as on variations and comparative aspects. After an introductory overview, the book outlines factors and conditions that affect RBC aggregation. It presents the two hypotheses—the bridging model and the depletion model—that provide potential mechanisms for the adhesive forces that lead to the regular packing of the cells in rouleaux formations. The book also reviews the methods used to quantify RBC aggregation in vitro, focusing on their importance in clinical practice. Chapters discuss the effect of RBC aggregation on the in vitro rheology of blood as well as on tube flow. The book also looks at what happens in the circulation when red blood cells aggregate and examines variations due to physiological and pathophysiological challenges. The concluding chapter explores the formation of red blood cell aggregates in other mammals. Written by leading researchers in the field, this is an invaluable resource for basic science, medical, and clinical researchers; graduate students; and clinicians interested in mammalian red blood cells.


Author
Publisher CRC Press
Release Date
ISBN 1439841802
Pages 318 pages
Red Blood Cell Aggregation
Language: en
Pages: 318
Authors: Oguz Baskurt
Categories: Medical
Type: BOOK - Published: 2011-09-28 - Publisher: CRC Press

Red blood cells in humans—and most other mammals—have a tendency to form aggregates with a characteristic face-to-face morphology, similar to a stack of coi
Red Blood Cell Aggregation Characterization
Language: en
Pages:
Authors: Rym Mehri
Categories:
Type: BOOK - Published: 2016 - Publisher:

Red blood cells (RBCs) are the most abundant cells in human blood, representing 40 to 45% of the blood volume (hematocrit). These cells have the particular abil
Red blood cell aggregation - rheological and microstructural characteristics
Language: en
Pages: 506
Authors: Efstathios C. Kaliviotis
Categories: Erythrocytes
Type: BOOK - Published: 2009 - Publisher:

The Red Blood Cell
Language: en
Pages: 782
Authors: Douglas MacN. Surgenor
Categories: Medical
Type: BOOK - Published: 2013-10-22 - Publisher: Academic Press

The Red Blood Cell, Second Edition, Volume II provides a comprehensive treatment and review of basic biomedical knowledge about the circulating, adult red blood
Discrete-element Model of Red Blood Cell Aggregation in Blood Flow
Language: en
Pages: 642
Authors: Jennifer Kathleene Wright Chesnutt
Categories: Erythrocytes
Type: BOOK - Published: 2009 - Publisher:

Handbook of Hemorheology and Hemodynamics
Language: en
Pages: 468
Authors: O.K. Baskurt
Categories: Medical
Type: BOOK - Published: 2007-10-03 - Publisher: IOS Press

This publication primarily focuses on the macro- and micro-rheological behavior of blood and its formed elements, on interactions between the formed elements an
Physical Characterization of Red Blood Cell Aggregation
Language: en
Pages:
Authors: Daniel Flormann
Categories:
Type: BOOK - Published: 2017 - Publisher:

Effects of Red Blood Cell Aggregation on Microparticle Margination in Human Blood
Language: en
Pages:
Authors: Mark Stroobach
Categories:
Type: BOOK - Published: 2017 - Publisher:

Margination is the migration of particles in a channel towards the outer walls of the channel. In blood microcirculation, studying the margination of microparti
Red Blood Cell Aggregation
Language: en
Pages: 318
Authors: Oguz Baskurt
Categories: Medical
Type: BOOK - Published: 2011-09-28 - Publisher: CRC Press

Red blood cells in humans—and most other mammals—have a tendency to form aggregates with a characteristic face-to-face morphology, similar to a stack of coi
Kinetics of Red Blood Cell Aggregation
Language: en
Pages:
Authors:
Categories:
Type: BOOK - Published: 1984 - Publisher:

The kinetics of the process by which red blood cells aggregate into long cylindrical, and sometimes branched, structures called rouleaux is studied within the f